Barry Milavetz, Ph.D., Professor
Project: Chromatin as an epigenetic regulator of the Simian Virus 40 lytic life cycle
Mentor: Barry Milavetz, Ph.D., Professor
Location: Department of Biomedical Sciences, Columbia Hall
Description: Using a virus, SV40, as a model to study the control of eukaryotic genes, we are dissecting the mechanisms responsible for epigenetic regulation. Our studies use a combination of chromatin immunoprecipitation, next-generation sequencing, defective CAS9 fusion proteins, and small molecule inhibitors of epigenetic regulators to determine how the combination of nucleosome location and histone modifications regulate transcription and replication. Our studies address fundamental questions related to eukaryotic molecular biology.
