NSF-REU
RESEARCH EXPERIENCES FOR UNDERGRADUATES FROM RURAL AND TRIBAL COLLEGES 

InvestigatorKurt Zhang, Ph.D. 

Location:  Department of Pathology, University of North Dakota

Project Title:  Gene regulatory networks for heart development
Description:  Heart is the first organ to develop in mammals.  The development of heart requires accurate regulation and expression of a large number of genes that form a spatiotemporal network.  Many environmental factors can perturb this fine network.  We use a mouse model to study the gene-gene dynamic interaction during heart development, and investigate how the network will adjust to environmental changes. This project needs both bench work and computational work.  We will collect gene expression data from mouse embryonic heart under various conditions, and construct a mathematic model to untangle the network structure and dynamic properties.